Using our BioResource

The aim of the NIHR BioResource is to further health research within the UK. We help research organisations with volunteer recruitment, specifically by genotype and/or phenotype.

We offer researchers the chance to select participants for studies based on their genetic make-up or on other characteristics, such as markers in their blood cells.

Our unique panel of participants has enabled researchers from around the world to make significant discoveries.

You can select participants based on defined characteristics, refining your analysis and increasing the chances of success.

There may be some costs involved.

Through the NIHR BioResource, researchers can choose participants based on their genetic make-up or on physical characteristics, such as markers in their blood cells.

This approach to participant selection can deliver advantages in refining a study to focus on the most suitable people. Resources in time and cost are saved in comparison to a broader recruitment strategy which relies on screening activities that the BioResource could otherwise undertake prior to participant enrolment.

For example, in a programme studying a common genetic variant that occurs in approximately 1 in 10 people, researchers would have to recruit about 500 participants to find 50 with the genetic variation of interest.

The NIHR BioResource approach is more time efficient: with 250,000 participants ready to take part, the process of identifying the 50 research-ready volunteers is far simpler and more efficient.

Our effort can be focused on identifying the participants needed for your study. If you submit a request, we can screen genetic or clinical data in advance of participant selection in line with the required criteria.

Consequently, we only invite to take part those people who have the genetic and/or phenotypic prerequisite that is important to your study. Valuable research is now possible into the causes of many diseases that previously would have proven too costly or time-consuming.

Our aim is to make your research more efficient.

The BioResource can support your research by providing clinical and/or genetic data, providing samples of DNA (blood/saliva), plasma or serum or by supporting you to recall our volunteers to take part in your research. Recall can be in the form of providing fresh samples, completing online questionnaires or taking part in a clinical trial.

To find out how to apply for support follow these links:

Apply for data Apply for samples Apply for recall

Our cohorts cover three main areas: common diseases, rare diseases, and general population.  Due to the specialist work needed to support COVID-19 research we also have a dedicated COVID-19 cohort.

Common diseases

Common diseases affect more than 2% of the population, often across age groups. Our national-scale recruitment covers Inflammatory Bowel Disease (IBD),  Immune-Mediated Inflammatory Diseases (IMID), Mental Health and Non-alcoholic Fatty Liver Disease (NAFLD).

Rare diseases

We aim to identify genetic causes of rare diseases, so improving rates of diagnosis, and enabling studies to develop and validate treatments.

We recruit affected participants and their relatives across several disease areas, including infection and immunity, neuroscience, rare cancers and cardiovascular disease. Click here for a full list of our rare diseases.

D-CYPHR

We have created the DNA, Children + Young People's Health Resource (D-CYPHR), with the aim of getting young people involved in research.

Since most research is carried out in adults, this research will help us understand the origins of disease, which often starts in childhood, as well as identify ways in which to prevent illnesses prior to adulthood.

COVID-19

We have created a special COVID-19 BioResource to support the rapidly expanding research in this field.

Several studies have now been supported and completed.

General population

Anyone with or without a health condition can join our general population cohort. We have over 125,000 general population volunteers made up of generous members of the public who want to help with medical and health research. These volunteers can be used in research looking at specific genes or as controls.

The NIHR BioResource works with researchers from both academia and industry. We have helped support over 300 studies resulting in over 330 publications.

The BioResource already includes a number of patient panels or cohorts, such as patients with IBD, heart conditions and autoimmunity. We would like to collaborate with clinicians who want to enrol patient groups.

If you run a clinic for a common or rare disease condition already on the BioResource panel, and are interested in recruiting patients to the NIHR BioResource, please get in touch. We make enrolling your patients as simple as possible.

Recruitment

How much does it cost?

Costs can be found on our costs page.

Who can apply?

Any researchers can apply, whether you are from industry, academia or a research institute.

How long does the process take? 

The time depends on what you are requesting and when you request it. Applications are reviewed on a quarterly basis and the committees decision is fed back within a week or two of the meeting. Samples are then usually shipped within 3-5 months. Recall studies can start as soon as approval is in place providing the required ethical approval and R&D approvals are in place.

What data do you have?

To find out more about what data we have please read the Apply for Data page.

How can I access samples?

To access samples please see the Apply for samples page. 

What is recall?

Recall is when we contact our panel of volunteers to ask them whether they would be interested in taking part in a particular study, this usually involves providing fresh samples, answering questionnaires or taking part in a clinical trial. 

Can you help with my application?

Yes, for help with your application please email us at nbr@bioresource.nihr.ac.uk