impaCt of bioLogic therApy on saRs-cov-2 Infection and immuniTY CLARITY

Study code
NBR77

Lead researcher
Dr Tariq Ahmad

Study type
Participant re-contact

Institution or company
Royal Devon and Exeter NHS Foundation Trust

Researcher type
Academic

Speciality area
Infection, COVID

Summary

SARS-CoV2 is a highly transmissible pulmonary infection that has triggered the first known coronavirus pandemic. It causes life-threatening pneumonia, especially in vulnerable patients, such as those with comorbidities.

 Inflammatory bowel disease (IBD) affects about 1% of the UK population, and like other immune-mediated inflammatory diseases (IMIDs) is usually treated with immunosuppressive therapies. The risk of SARS-CoV2 infection in IBD and the impact of immunosuppressive treatment is unknown. This study will harness a nationwide clinical network of specialist IBD centres across the UK to determine the prevalence of SARS-CoV2 infection and how different immunosuppressive treatments impact induction of protective immunity. In summary, this study will provide critical insights into how IMIDs and their treatments impact SARS-CoV2 infection risk and the establishment of protective immunity. These data hold the key to evidence-based public health policy decisions for these vulnerable patient groups.