Risk factors of chronic pain in patients with Inflammatory bowel disease
Prof Qasim Aziz
Institution or company
Wingate Institute for Neurogastroenterology
Background and Aim
Abdominal pain is a common symptom in patients with inflammatory bowel disease (IBD). Up to 70 % of IBD patients experience pain when the disease is active. Even when patients with IBD are in remission, 20-50 % of patients experience ongoing pain. The precise mechanism of developing chronic abdominal pain in patients with IBD in remission remains unknown.
The aim of this study is to identify psychophysiological and biological risk factors for the development of chronic abdominal pain in patients with newly diagnosed IBD. We then use cutting edge techniques in machine learning to ascertain if artificial intelligence can predict the development of chronic abdominal pain.
This study consists of 4 sections (Study 1A, 1B, 2, and 3).
Study 1A: We perform a longitudinal study in 150 patients with new-onset IBD (UC and CD) over 18 months. We will ask the participants to answer online questionnaires and record heart rate using a mobile app every 6 months. We will also ask them to participate in the IBD BioResource Inception study as well. Data collected by the IBD BioResource Inception study will be used in the analysis.
Study 1B: 450 patients who are newly registered in the Inception study will be recruited and followed for at least 12 months. We will ask them to answer online questionnaires every 6 months. Data collected by the IBD BioResource Inception study will be used in the analysis.
Study 2 and 3: Study 2 and 3 are a questionnaire-based cross-sectional study in patients with IBD (both CD and UC patients). The participants for study 2 are patients who are registered in IBD BOOST study, and those for study 3 are patients who are registered in IBD BioResource (but not in IBD Boost study). We will ask them to answer online questionnaires once.