Clinical Burden of Refractory Proctitis

Study code
NBR130

Lead researcher
Dr Gordon W Moran

Study type
Online

Institution or company
Nottingham University Hospitals NHS Trust

Researcher type
Academic

Speciality area
Gastroenterology

Recruitment Site
National

Summary

Refractory  proctitis  is  a  prevalent  problem  and  a  large  unmet  need  in  Inflammatory Bowel Disease (IBD). In patients whose disease does not progress and remains confined to the rectum, ulcerative proctitis is still often responsible for distressing symptoms such as urgency, incontinence, and constipation and rectal bleeding, leading to a  reduced quality of life.

Refractory disease is defined as active proctitis which fails rectal and oral therapy. Treatment of refractory proctitis remains challenging because patients with the condition are systematically excluded from randomized controlled trials with drugs with new modes  of  action.  Without this data, recommendations  for  the  management  of ulcerative  proctitis  are  therefore  often  extrapolated  from  studies  involved  more  in ulcerative colitis  or  from  small  real-world  evidence  studies. 

We  aim  to  use  the  patient and  clinical  experience  of  managing  ulcerative  proctitis  to  identify  the  clinical  and research  needs  of  this  patient group.  We  will  use  this  information  to  inform  future research and clinical guidance on this condition.