Genome-wide association studies of circulating blood metabolites

Study code
NBR13

Lead researcher
Prof. Tim Spector

Study type
Data only

Institution or company
King's College London

Speciality area
Genomics and Rare Diseases

Summary

Metabolites are small molecules that vary widely across individuals as a result of genetic and environmental exposures. They are the bridge between our genes and diseases. We want to identify genetic markers of human metabolites to improve our understanding of diseases and potentially new drug development

This research was carried out over a period of 4 years. We measured 722 metabolites in plasma in 8809 individuals and looked at whether their levels varied depending on each individual genetic make-up. 

We are reporting 74 novel genomic regions that influence human metabolism.  Our results shed light on genetic mechanisms controlling human metabolism, which can have many practical implications. We need to further investigate how the genes identified control of metabolic processes.

We would like to thank all of the individuals who volunteered to participate in this Study.