Cardiopulmonary exercise testing following COVID-19 infection

Study code

Lead researcher
Dr Jonathan Fuld

Study type
Participant re-contact

Institution or company
Cambridge University Hospital NHS Foundation Trust

Researcher type

Speciality area
COVID, Cardiovascular Disease


The coronavirus disease pandemic has led to a number of previously fit and healthy individuals presenting with post-Coronavirus Disease 2019 (COVID-19) syndrome.

Although poorly understood, symptoms including breathlessness on exertion, persistent cough, palpitations and “brain fog” have been described.  Pathways to investigate patients presenting with ongoing symptoms following acute Covid-19 infection have been proposed for primary and secondary care. 

Cardiopulmonary exercise testing (CPET), which assesses heart and lung function as a subject exercises up to their maximum capacity, may be helpful in further investigating heart, lung or muscle changes responsible for reduced exercise capacity and exertional symptoms in these patients.  CPET has an established role in diagnosing and staging heart and lung disease as well as quantifying aerobic fitness and revealing the cause of unexplained breathlessness. We will hopefully gain new insights into the problems people face as well as appropriate treatment after COVID.  It cannot be assumed that the graded approach to exercise used for sufferers of ME/CFS is appropriate for post COVID-19 patients, with personalised exercise prescription recommended by NICE.  

In the knowledge of varying clinical presentation and symptom progression following acute Covid-19 infection we are undertaking and analysing exercise responses in up to 80 patients who have previously had COVID who are willing to undertake the test.

We are currently beginning to conduct the tests and soon plan to analyse and share the results as well as relate them to other patient findings. 

Participation: For this study we recruited 15  participants from the COVID-19 BioResource to undertake a cycle exercise test know as a Cardiopulmonary Exercise Test (CPET) and to give a single blood sample.

Organisation: This study is organised by Dr Jonathan Fuld at Cambridge University Hospitals, Addenbrooke’s hospital, in Cambridge.