Assessment of efficacy and adverse events following SARS-CoV-2 cohort of subjects previously infected with COVID-19

Study code
NBR112

Lead researcher
Dr James Thaventhiran

Study type
Participant re-contact

Institution or company
MRC

Speciality area
Infection

Summary

Currently it is unclear if existing COVID-19 immunity generated by prior exposure increases the chance of adverse reactions COVID-19 vaccination or a blunting of vaccine efficacy. We are in a unique position to assess this as we have recently collected blood samples from a cohort of subjects that will be imminently offered the vaccine. We will quantitatively measure adaptive immunity prior to vaccination in these subjects and assess the correlation of this with either vaccine adverse effects or vaccine efficacy.