The UK Inflammatory Bowel Disease BioResource: Progressing from Genetics to Function and Clinical Translation in Crohn’s Disease & Ulcerative Colitis
Study code
NBR011
Lead researcher
Dr Miles Parkes
Study type
Samples and data
Institution or company
University of Cambridge
Researcher type
Academic
Speciality area
Gastroenterology, Genomics and Rare Diseases
Recruitment Site
National
Summary
The IBD BioResource is a collaboration between the UK IBD Genetics Consortium and the NIHR BioResource, with the aim of collecting samples (including DNA) and phenotype data from a cohort of 25,000 individuals with Crohn’s disease or ulcerative colitis. These subjects will be subject to GWAS and in due course to whole genome sequencing.
The current proposal is to allow UKIBDGC analysts to access GWAS data and phenotype data on patients recruited to the IBD BioResource. As part of a reciprocal arrangement, patients recruited to IBD BioResource who have previously been through the UKIBDGC pipeline will have GWAS data uploaded from UKIBDGC to IBD BioResource.
The proposal includes supply of an aliquot of extracted DNA for each patient for baseline genomic analysis.
GWAS and phenotype data will then be used in the range of on-going genetic analyses lead by UKIBDGC, including fine mapping to define causal variants, interrogation of low-frequency and rare variants, and sub-phenotype and pharmacogenetic analyses.
For further information see here: IBD BioResource