Defining the mechanisms and control of human regulatory T cell function in autoimmunity

Study code
NBR08

Lead researcher
Prof. Graham Lord

Study type
Participant re-contact

Institution or company
King’s College London

Speciality area
Infection, Metabolic and Endocrine Disorders, Gastroenterology

Summary

We still lack a detailed understanding of how the immune system is regulated in the healthy human, and how dysregulation contributes to disease. Specifically, we need to understand how regulatory T cells (Tregs) control other immune pathways, how and where Tregs act and interact with other immune and inflammatory components, and how this understanding might be harnessed to treat autoimmune disease. This research will help move us forward in this field.

We have a strong commitment to translational research with ongoing clinical research into the immunology of transplantation, inflammatory bowel disease and sepsis. This includes projects investigating both novel biomarkers in these diseases and cutting-edge therapies, including cellular therapy.