Improving our understanding of how genetic variants alter body weight regulation and diabetes risk

Study code
CBR6

Lead researcher
Dr David Savage

Study type
Participant re-contact

Institution or company
University of Cambridge

Researcher type
Academic

Speciality area
Diabetes

Recruitment Site
Cambridge

Summary

We all have genes which control things about us like hair colour, eye colour, weight etc. We also have lots of variation in our genes which is why we all look different. Such genetic variants are very common. Scientists have thought for some time now that these common genetic variants might contribute to inherited differences in people’s susceptibility to weight gain and diabetes. However, this idea has been very difficult to prove.

Very recently scientists have identified common genetic variants in a number of genes which appear to have an effect on body weight and tendency to develop diabetes later in life. How these genetic changes alter the tendency to gain weight and risk of diabetes is currently unknown.

The purpose of this study is to improve our understanding of how genetic variants alter body weight regulation and diabetes risk. Specifically we would like to measure how much you eat and how much energy your body uses up under carefully controlled conditions. The reason for wanting to understand this issue better is to try to identify more effective ways of preventing weight gain and reducing the incidence of diabetes.