Genetic and cellular mechanisms protecting from tuberculosis
Dr Sergey Nejentsev
Institution or company
University of Cambridge
The purpose of this study is to find the genes and to understand biological mechanisms that are involved in protecting humans from infectious diseases, in particular, from tuberculosis. Tuberculosis remains a global health problem. Every year there are approximately 9 million new patients and more than 1 million deaths due to tuberculosis. Currently available vaccine called BCG does not prevent pulmonary tuberculosis, the most common form of the disease. New, more efficient vaccines are required. However, to design such vaccines researchers need to better understand biological mechanisms of infection and immunological protection against it. Our study is designed to collect this valuable information.
Participation: For this study we recruited 1405 volunteers from the Cambridge BioResource to give a 45ml blood sample.