The role of cell surface proteins on immune cells called Natural Killer Cells

Study code
CBR185

Lead researcher
Dr David Adams

Study type
Participant re-contact

Institution or company
Wellcome Trust Sanger Institute,

Researcher type
Academic

Speciality area
Cancer

Recruitment Site
Cambridge

Summary

The aim of the study is to determine the role of cell surface proteins on a type of immune cell called a Natural Killer (NK) cell. The study aims to investigate how these cell surface proteins on the NK cells interact with proteins expressed on other cells, in particular, cancer cells.

NK cells can kill cancer cells but we believe that cancer cells evade NK cells by expressing different proteins on their surface or reducing expression (production) of certain proteins. By functionally characterizing these protein interactions we will identify new candidates which could be helpful, in the future, in the design of cancer therapies.