Helper T-cell ageing (HELPAGE) - Research Towards Immunisations that Last

Study code
CBR169

Lead researcher
Dr Michelle Linterman

Study type
Participant re-contact

Institution or company
Babraham Institute

Researcher type
Academic

Speciality area
Cross-cutting, Ageing

Recruitment Site
Cambridge

Summary

A major accomplishment of modern society is the extension of human life expectancy. However, this creates a new challenge for medical science, to facilitate healthy ageing. With age, the immune system does not respond as well to vaccination, our research aims to determine why this occurs, and if there is anything we’re able to do to improve vaccine responsiveness.  

Vaccination results in a coordinated effort of multiple type of white blood cells that act together to generate immunological memory, which provides protection against subsequent infection. Helper T cells are one of the key white blood cell types involved. They support the production of antibodies that can prevent an infection from spreading. The Linterman group is focused on understanding the roles that helper T cells play in the response to immunization and the molecular changes in these cells that result the age-dependent decline in vaccine responses.