Genetic Variation AND Altered Leucocyte Function in health and disease (GANDALF): Molecular mechanisms

Summary

We are studying factors that affect regulation of the immune system. The immune system has the complex task of protecting the body against infectious organisms without attacking its own tissues. Without a well functioning immune system we are susceptible to a vast array of viral, bacterial, fungal and parasitic infections. However, when the immune system acts against the body it can cause important "autoimmune" diseases including rheumatoid arthritis, vasculitis and systemic lupus erythematosus (SLE).

Genetic variation between individuals can affect the way their immune system responds to infections, and may predispose some individuals to autoimmune disease. In addition, genetic variation may affect the way the immune system is affected by immune suppressant drugs, as well as the likelihood of rejection after a transplant.

We plan to study the way the immune system responds to stimuli including infectious organisms and immune complexes. In particular, we wish to further investigate how genetic differences between individuals affect the way their white blood cells respond under a number of conditions. We hope a better understanding of how genetic variation affects immune responses will lead to new ways to treat infections, transplant rejection and autoimmune disease.

Participation: For this study we recruited 147 participants from the Cambridge BioResource. Visits took place at the Cambridge BioResource's clinical facility on the Cambridge Biomedical campus.

Organisation: This study is organised by Professor Ken Smith from the Department of Medicine, the University of Cambridge.