Molecular investigation of genetic factors in CArDiovascular diseases and liver disease using a BIOresource of healthy volunteers (CADBIO)

Study code
CBR145

Lead researcher
Dr.Dirk Paul

Study type
Participant re-contact

Institution or company
University of Cambridge

Researcher type
Academic

Speciality area
Cardiovascular Disease, Liver

Recruitment Site
Cambridge

Summary

 Our study aims to determine the distinct molecular mechanisms underlying functional genetic variants identified in large-scale genome-wide association studies (GWAS) for cardiovascular disease. We will measure a range of cellular and physiological indicators in healthy volunteers who carry such functional variants versus those who do not, at one of three genetic regions of interest (PNPLA3, PROCR and EDNRA). Results from this study will reveal novel insights into the pathophysiology of cardiovascular disease, potentially leading to better diagnosis, tailored prevention and treatment of the disease.