Investigation into the frequency of anti-immunoglobulin autoantibodies in humans that bind to GSK2862277 (a variable heavy chain domain antibody targeting human TNFR1) and the potential for dAb:autoantibody complexes to activate TNFR1 signalling

Summary

Vasculitis is an autoimmune disease which involves inflammation of the blood vessels. Many patients with vasculitis will have very different types of disease but the basic problem is still the same – inflammation of the blood vessels. We plan to look for differences in the patterns of genes between approximately 2,500 patients with vasculitis and a similar number of healthy individuals. By doing this we hope to identify genes which make the development of vasculitis more likely. This then may help us to develop new treatments for vasculitis. 

Participation: For this study 203 stored samples from Cambridge BioResource volunteers were used. 

Organisation: This study is organised by Professor Ken Smith at the Department of Medicine in the Cambridge Institute for Medical Research situated on the Addenbrooke’s hospital site in Cambridge.