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publication

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

Frontiers in Immunology
Corridoni, D., Shiraishi, S., Chapman, T., Steevels, T., Muraro, D., Thézénas, M., et al.

30 April 2019

publication

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

Nature Communications
Espéli, M., Bashford-Rogers, R., Sowerby, J., Alouche, N., Wong, L., Denton, A., et al.

29 April 2019

study

Genetic Variation in Coagulation Factors and Risk of Haemorrhage

Lead: Ms Erlinda Dedgjonaj

Genomics and Rare Diseases
Haematology

study

Validation of spinal muscular atrophy copy-number caller using 13,000 whole-genome sequence data

Lead: Ms Adeela Ahmad

Genomics and Rare Diseases

study

COvid-19 PsychIatry and Neurological Genetics (COPING) study

Lead: Professor Gerome Breen

Mental Health
Genomics and Rare Diseases
Neurological Disorders
COVID

publication

Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children

Intensive Care Medicine
French, C., Delon, I., Dolling, H., Sanchis-Juan, A., Shamardina, O., Mégy, K., et al.

7 March 2019

news

Rare Disease Day Cambridge Lecture

7 March 2019

Rare disease

publication

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

The Lancet. Respiratory Medicine
Rhodes, C., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., et al.

1 March 2019

study

METRIC-EF: Magnetic Resonance Enterography and Small Bowel Ultrasound as predictors of disabling disease in newly-diagnosed Crohn’s disease

Lead: Prof. Stuart Taylor

Gastroenterology

study

SPIT Study - Diagnosing Crohn's disease based on salivary epigenetics

Lead: Professor Laurence Lovat

Gastroenterology
Genomics and Rare Diseases

study

LATTICE – Safety &amp

Lead: Dr Tim Raine

Gastroenterology

study

GENBIO-SWAP70 – Identifying the cell type-specific roles of the coronary artery disease risk gene SWAP70

Lead: Dr Dirk Paul

Cardiovascular Disease

study

A longitudinal study of reproductive choices in women with inflammatory bowel disease

Lead: Dr Christian Selinger

Gastroenterology

study

MODULATE – Management of diarrhoea in ulcerative colitis

Lead: Professor Alexander Ford

Gastroenterology

study

The effect of SSRIs on threat of shock potentiated neural circuitry

Lead: Dr Oliver Robinson

Mental Health

study

Functional analysis of primary immunodeficiency-associated gene variants

Lead: Professor Ken Smith

Genomics and Rare Diseases

study

ROTEC – Inherited changes leading to altered levels of a blood protein, tissue factor pathway inhibitor and risk of cardiovascular disease

Lead: Dr William Astle

Haematology
Cardiovascular Disease

study

IBD Risk Alleles – Effect of genetic variants associated with risk for inflammatory disease on immune cell phenotype and function.

Lead: Dr Carl Anderson

Gastroenterology

study

ROVIM – Role of blood group VEL in metabolism.

Lead: Dr Mattia Frontini

Metabolic and Endocrine Disorders
Haematology

study

Understanding contributions of T cell determining factors in the pathogenesis of IBD

Lead: Prof. Adrian Hayday

Gastroenterology

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