Genetic data from SNP chips/arrays

The NIHR BioResource holds genetic data on many of its participants that may be used for data-only research or as a basis of selection to future experimental medicine studies.

To give a sense of the scale of the current holding, this is a snapshot from March 2019:

Chip/Array Vendor Number of samples typed Number of unique participants Number of recallable participants Number of samples available for data re-use
PFC Illumina 398 398 344 367
Ominiexpress chip Illumina 1078 1078 743 916
Immuno chip Illumina 3851 3845 2713 3263
Exome chip Illumina 2686 2684 2022 2297
Core exome V1.0 & V1.1 chip Illumina 3549 3542 2783 3060
MS exome chip Illumina 1496 1493 1173 1293
Affymetrix V1.0 Thermofisher 58748 57529 34230 46793

Notes:

  1. This table excludes ~7,000 recallable participants recruited to the previous NIHR BioResource – Rare Diseases, who have Whole Genome Sequencing available;
  2. Not all participants are available at all times – we may only invite each person to 4 studies per year – and not all will want to join any given study;
  3. However, the number of recallable participants is increasing both as we commission more genotyping – with the revised version of the UK Biobank Axiom (v2.1) chip – and as more participants’ details are added to the central recall database.