AdipO2 – Body fat distribution and diabetes risk: the role of adipose tissue oxygen metabolism
Dr Konstantinos Manolopoulos
Samples and data
Institution or company
University of Birmingham
Metabolic and Endocrine Disorders
Fat tissue plays an important role in human metabolism as it stores energy derived from meals. However, fat accumulation as seen in obesity is associated with cardiovascular disease and the development of diabetes, and is also linked to inflammation. In this research project, we will study the relationship between fat tissue oxygen metabolism (an important metabolic factor) and inflammation in lean and obese subjects. We wish to explore the mechanisms by which oxygen affects abdominal and thigh fat function including nutrient handling and the production of inflammatory factors, since a deeper understanding of these mechanisms could pave the way for future treatments of obesity complications. We will conduct an in vivo physiology study in healthy lean and obese postmenopausal female volunteers that will allow us to study fat tissue function under near-normal conditions. The in vivo study involves taking blood samples from veins specifically draining fat tissue before and after a standardised high-fat meal, alongside measurements of fat tissue blood flow. These measurements are supplemented with extensive lab-based characterisation of fat tissue from biopsies taken during the in vivo study.