Evaluation of the immune response to vaccines in patients previously infected with COVID-19 : COV-VAX-IR

Study code
NBR100

Lead researcher
Dr Anita Chandra

Study type
Participant re-contact

Institution or company
Cambridge University Hospital NHS Foundation Trust

Speciality area
Infection

Summary

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to significant morbidity and mortality.

Recent studies have suggested that some patients have evidence of persistent defects in their immune system. These problems in the immune system can leave patients vulnerable to recurrent infections and autoimmunity and therefore a better understanding of the effect of COVID-19 infection on the immune system is required. We can test the immune system by assessment of the immune response following immunization with routine and safe vaccines.

In this study we will test immunize patients who have previously experienced COVID-19 infection to assess whether they have functional evidence of an immune defect.

Identification of immunodeficiency is important as this will help understand the long-term effects of COVID-19 on the immune system, alter future clinical management of these individuals and will have impact on public health measures.